Interaction of Docetaxel (“Taxotere”) with Human P-Glycoprotein
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چکیده
منابع مشابه
Interaction of antiepileptic drugs with human P-glycoprotein in vitro.
About one-third of epilepsy patients are resistant to treatment with antiepileptic drugs (AEDs). This refractoriness is not fully understood, but is thought to be attributed to overexpression of multidrug transporters at the blood-brain barrier, particularly P-glycoprotein (Pgp). In certain cases pharmacoresistance can be overcome by add-on therapy, raising the question of whether the coadminis...
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Docetaxel activity has been documented in many solid tumors, including metastatic breast cancer and non-small cell lung cancer. However, as clinical studies in other tumor types are now being conducted, the validation of an optimal sampling strategy would allow the performance of pharmacokinetics/pharmacodynamics studies with minimum inconvenience for the patient. Six optimal sampling strategie...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1999
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1999.tb00723.x